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Scar Formation

Overview & Proposed Solution

Our solution is based on a combination of different genes, rather than just one:

  • We aim at creating a gene therapy DNA vector VTvaf17 carrying SKI, TGFB3, TIMP2, and FMOD therapeutic genes for a scar treatment therapy.

  • Previous research results have shown that insufficient expression of proteins encoded by these genes are associated with the development of a spectrum of diseases, including, but not limited to, autoimmune diseases, hereditary and acquired pathological conditions, such as connective tissue damage, and other processes.

  • Therefore we believe that genetic constructs that provide expression of proteins encoded by a combination of those genes can be used to develop drugs for the treatment of scars and damaged skin tissue

  • The genetic constructions described above have been separately filed for patent and the respective strains have been deposited in an international depository.

Competitive Therapies

  • There is a variety of treatments available for scars, such as topical, injectable, cryotherapy, radiotherapy, laser therapy and mechanical;

  • Although the treatment of scars with current individual or combination therapy can improve the physical appearance of scars, those therapies have limited effectiveness;

  • No currently available scar therapy is universally successful.

Further Advantages:

  • Huge market size that is growing fast due to a number of different factors (see next slide);

  • Little competition in the gene therapy space;

  • Although numerous scar treatment therapies currently exist, none of them is universally successful.

Market Trends & Projections

Market Size Growth Forecast (2018 – 2026)



The main factors that are increasing the market  share for scar treatment are:

  • rising rate of road accidents;

  • increasing count of the population with burn injuries;

  • increasing count of skin diseases leading to permanent scars (Acne scars being most common);

  • growth in surgical interventions causing permanent scars;

  • moreover, growing disposable income, technological advancement for scar treatment, and raising awareness among people regarding aesthetics are also boosting market growth.

Projections of Sales in the first 5 Years


Assumptions and Rate Definitions:
Incidence Rate: Average percentage of disease occurrence across the population.

Diagnosed Population: Percentage of the population with a correctly diagnosed disease.
Patients seeking new therapy: Diagnosed patients that are actively searching for alternative remedies for their illness; and are able and willing to undergo a new treatment.

Compliance rate: Out of the patients, who are actively seeking an alternative therapy, it is the percentage that actually make the switch and select a new therapy.

Patent information:

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