Scar Formation
Overview & Proposed Solution
Our solution is based on a combination of different genes, rather than just one:
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We aim at creating a gene therapy DNA vector VTvaf17 carrying SKI, TGFB3, TIMP2, and FMOD therapeutic genes for a scar treatment therapy.
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Previous research results have shown that insufficient expression of proteins encoded by these genes are associated with the development of a spectrum of diseases, including, but not limited to, autoimmune diseases, hereditary and acquired pathological conditions, such as connective tissue damage, and other processes.
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Therefore we believe that genetic constructs that provide expression of proteins encoded by a combination of those genes can be used to develop drugs for the treatment of scars and damaged skin tissue
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The genetic constructions described above have been separately filed for patent and the respective strains have been deposited in an international depository.
Competitive Therapies
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There is a variety of treatments available for scars, such as topical, injectable, cryotherapy, radiotherapy, laser therapy and mechanical;
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Although the treatment of scars with current individual or combination therapy can improve the physical appearance of scars, those therapies have limited effectiveness;
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No currently available scar therapy is universally successful.
Further Advantages:
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Huge market size that is growing fast due to a number of different factors (see next slide);
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Little competition in the gene therapy space;
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Although numerous scar treatment therapies currently exist, none of them is universally successful.
Market Trends & Projections
Market Size Growth Forecast (2018 – 2026)
Comments
The main factors that are increasing the market share for scar treatment are:
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rising rate of road accidents;
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increasing count of the population with burn injuries;
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increasing count of skin diseases leading to permanent scars (Acne scars being most common);
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growth in surgical interventions causing permanent scars;
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moreover, growing disposable income, technological advancement for scar treatment, and raising awareness among people regarding aesthetics are also boosting market growth.
Projections of Sales in the first 5 Years
Assumptions and Rate Definitions:
Incidence Rate: Average percentage of disease occurrence across the population.
Diagnosed Population: Percentage of the population with a correctly diagnosed disease.
Patients seeking new therapy: Diagnosed patients that are actively searching for alternative remedies for their illness; and are able and willing to undergo a new treatment.
Compliance rate: Out of the patients, who are actively seeking an alternative therapy, it is the percentage that actually make the switch and select a new therapy.
Patent information: