
Innovative Gene Therapy for
Alzheimer's Disease

Introduction
Our pioneering genetic pharmaceutical represents a breakthrough in Alzheimer's Disease (AD) treatment - CG-AD211 - integrating proven methods with cutting-edge biotechnology. We focus on two major therapeutic objectives:
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Clearance of Intracellular Pathological Protein Aggregates
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Neuroregeneration in Affected Brain Regions
Therapeutic Strategy
Our approach targets the core pathological processes of Alzheimer's:
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Selective Removal of Intracellular Tau Aggregates: Our innovative therapy directly targets the accumulation of intracellular tau aggregates—recognized as a primary cause of neurodegeneration and cognitive decline in Alzheimer's Disease. Unlike conventional treatments primarily aimed at reducing inflammation or managing secondary symptoms, our approach tackles the underlying pathology by facilitating the intracellular disposal of tau proteins. Currently, no other treatment provides this targeted solution.
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Promoting Neuroregeneration: By leveraging native human genes, our therapy actively stimulates multiple regeneration processes within the brain. It supports damaged neurons in their recovery and enhances their capability to re-establish functional synaptic connections. Additionally, our therapy provides robust neuroprotective effects, safeguarding existing neurons from further degeneration. This combined approach of neuron repair and neuroprotection ensures effective reintegration into existing neural networks, ultimately resulting in significant improvements in cognitive and neurological functions for Alzheimer's patients.
Advanced Genetic Tools
Our therapeutic innovation is based on patented non-viral DNA vectors, combining efficacy, safety, and precision:
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Non-viral DNA vectors (VTvaf17 and GDTT1.8NAS): Our unique, innovative genetic delivery platforms designed specifically for gene therapy of various diseases. These vectors offer exceptional safety and efficacy, completely avoiding genome integration and minimizing side effects. They enable precise, controlled expression of therapeutic genes, maximizing treatment outcomes.
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Dual Promoter Technology: Using neuron-specific and inflammation-activated promoters, our vectors ensure that therapeutic genes are expressed only in targeted neurons affected by AD, dramatically reducing unwanted effects elsewhere in the body.
Precision Delivery System
Our drug is delivered directly to the brain through advanced encapsulation technology:
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Liposomal Delivery (DNA + Cationic Liposome + PEG): This complex primarily ensures high transfection efficiency, protects the DNA vectors encoding therapeutic genes, and significantly enhances the drug's ability to penetrate the blood-brain barrier, facilitating targeted delivery directly to neurons.
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Functionalization for Enhanced Targeting: Specialized reagents functionalize our microspheres, improving affinity for neuronal receptors and maximizing therapeutic effects specifically in affected areas.
Economic and Clinical Viability
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Economic and Clinical Viability
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Regulatory Compliance: Meets all EMA and FDA standards for safety and efficacy.
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Scalable Production: Compatible with standard biotechnological facilities, ensuring affordability and high profitability.
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Market Potential: Addresses an unmet need in an expanding global market, projected to triple by 2050.
Future Expansion
Potential application of our genetic pharmaceutical extends beyond Alzheimer's to other neurodegenerative conditions like Parkinson's Disease, tauopathies, and Multiple Sclerosis, highlighting the versatility and broad therapeutic impact of our innovation.
For collaboration, investment, or detailed inquiries, please contact our team directly.